Cancer develops due to specific changes such as a mutation or phosphorylation of key molecules (target) in normal cells leading to its altered function. These changes are often patient specific. Targeted drugs associate with these molecules and destroy cancer cells. Our team of experienced cancer researchers deploy the most innovative and contemporary approaches to new drug design and are developing a proprietary targeted drug for common forms of leukemia in children and adults.
Patients taking a particular drug for their cancer treatment often become resistant to that drug. This resistance is due to new mutations that occur in the cancer cells. Identification and molecular characterization of these mutations is necessary to develop new drugs for these patients. Therapy architects is developing new drugs for treating drug resistance in adult leukemia.
The outer surface of cancer cells has molecules designated as cancer biomarkers, that are absent in normal cells. In tumor targeted drug delivery, these unique molecules are utilized to deliver drugs specifically into cancer cells. Therapy Architects is developing nanoparticles mediated targeted drug delivery for leukemia in children and adults.
ALLCRON Pharma Inc., a fully owned subsidiary company of Therapy Architects, LLC. has licensed on a worldwide exclusive basis, the intellectual property of the new anti-leukemia drug candidatefor the treatment of advanced life threatening Chronic Myelogenous Leukemia (CML). ALLCRON Pharma (AP) will lead the development and Phase 1 trial for the drug.
CML is one of the most common blood cancers in adults. There are three stages in this disease: chronic, accelerated and blast crisis. Bcr-Abl is an enzyme that makes leukemic cells to replicate in an uncontrolled manner. Currently, CML patients are treated by a Bcr-Abl targeted drug called Gleevec. Gleevec stops the action of Bcr-Abl and kills leukemic cells.
Bcr-Abl is present in all three stages of CML. However, only patients in chronic phase fully respond to Gleevec. In accelerated phase and blast crisis, mutations in the Bcr-Abl results in the development of resistance to Gleevec. Consequently, patients with Gleevec resistance are treated with second generation and third generation Bcr-Abl inhibitors, One of these Bcr-Abl mutations, designated as T315I is very dangerous and patients with this mutation in the Bcr-Abl gene have limited treatment options.
ALLCRON’s chemical genomics approach has produced a promising leukemia targeted small molecule drug candidate that shows promising activity against CML. ALLCRON has a clinical candidate which combats Bcr-Abl T315I drug resistance that will ultimately improve survival.
Therapy Architects designs and develops novel targeted cancer therapies for both children and adults. Every patient is unique and not all respond to available products. Our team is focused on improving outcomes by optimizing efficacy and reducing toxic side effects of chemotherapeutic agents where, the cure can sometimes be worse than the disease itself.
© 2016 Therapy Architects. All rights reserved